Hair research laboratory team ORIGINAL RESEARCH publications

Lo BK, Yu M, Zloty D, Cowan B, Shapiro J, McElwee KJ. CXCR3/ligands are significantly involved in the tumorigenesis of basal cell carcinomas. Am J Pathol. 2010 May;176(5):2435-46.

Warnock F, McElwee K, Seo RJ, McIsaac S, Seim D, Ramirez-Aponte T, Macritchie KA, Young AH. Measuring cortisol and DHEA in fingernails: a pilot study. Neuropsychiatr Dis Treat. 2010 Feb 3;6:1-7.

Yu M, Bell RH, Ross EK, Lo BK, Isaac-Renton M, Martinka M, et al. Lichen planopilaris and pseudopelade of Brocq involve distinct disease associated gene expression patterns by microarray. J Dermatol Sci. Jan 2010 Jan;57(1):27-36.

Hamilton T, Otberg N, Wu WY, Martinka M, Shapiro J. Successful hair re-growth with multimodal treatment of early cicatricial alopecia in discoid lupus erythematosus. Acta Derm Venereol. 2009;89(4):417-8.

Strober BE, Menon K, McMichael A, Hordinsky M, Krueger G, Panko J, et al. Alefacept for severe alopecia areata: a randomized, double-blind, placebo-controlled study. Arch Dermatol. 2009 Nov;145(11):1262-6.

Blume-Peytavi U, Atkin S, Shapiro J, Lavery S, Grimalt R, Hoffmann R, et al. European Consensus on the evaluation of women presenting with excessive hair growth. Eur J Dermatol. 2009 Nov-Dec;19(6):597-602.

Otberg N, Wu WY, Kang H, Martinka M, Alzolibani AA, Restrepo I, et al. Folliculitis decalvans developing 20 years after hair restoration surgery in punch grafts: case report. Dermatol Surg. 2009 Nov;35(11):1852-6.

Calderon P, Otberg N, Shapiro J. Uncombable hair syndrome. J Am Acad Dermatol. 2009 Sep;61(3):512-5.

Restrepo I, Otberg N, McElwee K, Shapiro J. Two sisters, two different hair shaft abnormalities. Br J Dermatol. 2009 Aug;161(2):479-80.

Wu WY, Otberg N, Kang H, Zanet L, Shapiro J. Successful treatment of temporal triangular alopecia by hair restoration surgery using follicular unit transplantation. Dermatol Surg. 2009 Aug;35(8):1307-10.

Hemmati I, Otberg N, Martinka M, Alzolibani A, Restrepo I, Shapiro J. Discoid lupus erythematosus presenting with cysts, comedones, and cicatricial alopecia on the scalp. J Am Acad Dermatol. 2009 Jun;60(6):1070-2.

Zhang X, Yu M, Yu W, Weinberg J, Shapiro J, McElwee KJ. Development of Alopecia Areata Is Associated with Higher Central and Peripheral Hypothalamic-Pituitary-Adrenal Tone in the Skin Graft Induced C3H/HeJ Mouse Model. J Invest Dermatol. Jun;129(6):1527-38.

Zhang J, Adam DN, Stebbing E, Gerbrandt J, Lui H, Shapiro J, Zhou Y. Efficacy of a day-care program in the treatment of psoriasis. J Cutan Med Surg. 2008 Sep-Oct;12(5):211-6.

Yu M, Zloty D, Cowan B, Shapiro J, Haegert A, Bell RH, Warshawski L, Carr N, McElwee KJ. Superficial, nodular, and morpheiform basal-cell carcinomas exhibit distinct gene expression profiles. J Invest Dermatol. 2008 Jul;128(7):1797-805.

Yu M, Kissling S, Freyschmidt-Paul P, Hoffmann R, Shapiro J, McElwee KJ. Interleukin-6 cytokine family member oncostatin M is a hair-follicle-expressed factor with hair growth inhibitory properties. Exp Dermatol. 2008 Jan;17(1):12-9.

Buckley C, Hoffmann V, Shapiro J, Saari S, Cambazard F, Milsgaard M. Calcipotriol plus betamethasone dipropionate scalp formulation is effective and well tolerated in the treatment of scalp psoriasis: a phase II study. Dermatology. 2008;217(2):107-13.

Hamzavi I, Tan E, Shapiro J, Lui H. A randomized bilateral vehicle-controlled study of eflornithine cream combined with laser treatment versus laser treatment alone for facial hirsutism in women. J Am Acad Dermatol. 2007 Jul;57(1):54-9.

Freyschmidt-Paul P, McElwee KJ, Hoffmann R, Sundberg JP, Vitacolonna M, Kissling S, Zöller M. Interferon-gamma-deficient mice are resistant to the development of alopecia areata. Br J Dermatol. 2006 Sep;155(3):515-21.

Freyschmidt-Paul P, Zoller M, McElwee KJ, Sundberg J, Happle R, Hoffmann R. The functional relevance of the type 1 cytokines IFN-gamma and IL-2 in alopecia areata of C3H/HeJ mice. J Investig Dermatol Symp Proc. 2005 Dec;10(3):282-3.

Ross EK, Bolduc C, Lui H, Shapiro J. Lack of efficacy of topical latanoprost in the treatment of eyebrow alopecia areata. J Am Acad Dermatol. 2005 Dec;53(6):1095-6.

Alajlan A, Shapiro J, Rivers JK, MacDonald N, Wiggin J, Lui H. Paradoxical hypertrichosis after laser epilation. J Am Acad Dermatol 2005;53(1):85-8.

McElwee KJ, Freyschmidt-Paul P, Hoffmann R, Kissling S, Hummel S, Vitacolonna M, Zoller M. Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model. J Invest Dermatol. 2005 May;124(5):947-57.

Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Arch Dermatol 2004;140(6):677-83.

Tan E, Martinka M, Ball N, Shapiro J. Primary cicatricial alopecias – a clinico-pathologic review of 112 cases. J Am Acad Dermatol 2004;50:25-32.

Tan L, Cao L, Sundberg JP, Lui H, Shapiro J. Restoration of hair growth in mice with an alopecia areata-like disease using topical anthralin. Exp Dermatol 2004;13(1):5-10.

Zoller M, McElwee KJ, Vitacolonna M, Hoffmann R. Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients. J Autoimmun. 2004 Nov;23(3):241-56.

Verma DD, Verma S, McElwee KJ, Freyschmidt-Paul P, Hoffman R, Fahr A. Treatment of alopecia areata in the DEBR model using Cyclosporin A lipid vesicles. Eur J Dermatol. 2004 Sep-Oct;14(5):332-8.

Zoller M, McElwee KJ, Vitacolonna M, Hoffmann R. The progressive state, in contrast to the stable or regressive state of alopecia areata, is reflected in peripheral blood mononuclear cells. xp Dermatol. 2004 Jul;13(7):435-44.

McElwee KJ, Huth A, Kissling S, Hoffmann R. Macrophage-stimulating protein promotes hair growth ex vivo and induces anagen from telogen stage hair follicles in vivo. J Invest Dermatol. 2004 Jul;123(1):34-40.

Zoller M, Freyschmidt-Paul P, Vitacolonna M, McElwee KJ, Hummel S, Hoffmann R. Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata. Clin Exp Immunol. 2004 Mar;135(3):398-408.

Bernardo O, Tang L, Lui H, Shapiro J. Topical nitrogen mustard in the treatment of alopecia areata: a bilateral comparison study. J Am Acad Dermatol 2003;49(2):291-4.

Shum DT, Lui H, Martinka M, Bernardo O, Shapiro J. Computerized morphometry and three-dimensional image reconstruction in the evaluation of scalp biopsy from patients with non-cicatricial alopecias. Br J Dermatol 2003;148(2):272-8.

Tang L, Bernardo O, Bolduc C, Lui H, Madani S, Shapiro J. The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia. J Am Acad Dermatol 2003;49(2):229-33.

Tang L, Cao L, Pelech S, Lui H, Shapiro J. Cytokines and signal transduction pathways mediated by anthralin in alopecia areata-affected Dundee experimental balding rats. J Investig Dermatol Symp Proc 2003;8(1):87-90.

Tang L, Cao L, Bernardo O, Chen Y, Sundberg JP, Lui H, Shapiro J, et al. Topical mechlorethamine restores autoimmune-arrested follicular activity in mice with an alopecia areata-like disease by targeting infiltrated lymphocytes. J Invest Dermatol 2003;120(3):400-6.

Tang L, Cao L, Sundberg JP, Lui H, Shapiro J. Restoration of hair growth in mice with an alopecia areata-like disease using topical anthralin. Exp Dermatol 2003;12:5-10.

Tang L, Lui H, Sundberg JP, Bissonnette R, McLean DI, Shapiro J. Restoration of hair growth with topical diphencyprone in mouse and rat models of alopecia areata. J Am Acad Dermatol 2003;49:1013-9.

McElwee KJ, Kissling S, Wenzel E, Huth A, Hoffmann R. Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. J Invest Dermatol. 2003 Dec;121(6):1267-75.

McElwee KJ, Silva K, Boggess D, Bechtold L, King LE Jr, Sundberg JP. Alopecia areata in C3H/HeJ mice involves leukocyte-mediated root sheath disruption in advance of overt hair loss. Vet Pathol. 2003 Nov;40(6):643-50.

Freyschmidt-Paul P, McElwee KJ, Botchkarev V, Kissling S, Wenzel E, Sundberg JP, Happle R, Hoffmann R. Fas-deficient C3.MRL-Tnfrsf6(lpr) mice and Fas ligand-deficient C3H/HeJ-Tnfsf6(gld) mice are relatively resistant to the induction of alopecia areata by grafting of alopecia areata-affected skin from C3H/HeJ mice. J Investig Dermatol Symp Proc. 2003 Jun;8(1):104-8.

Sundberg JP, Boggess D, Silva KA, McElwee KJ, King LE, Li R, Churchill G, Cox GA. Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Invest Dermatol. 2003 May;120(5):771-5.

McElwee KJ, Niiyama S, Freyschmidt-Paul P, Wenzel E, Kissling S, Sundberg JP, Hoffmann R. Dietary soy oil content and soy-derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice. Exp Dermatol. 2003 Feb;12(1):30-6.

Tang L, Madani S, Lui H, Shapiro J. Regeneration of a new hair follicle from the upper half of a human hair follicle in a nude mouse. J Invest Dermatol 2002;119(4):983-4.

McElwee KJ, Hoffmann R, Freyschmidt-Paul P, Wenzel E, Kissling S, Sundberg JP, Zoller M. Resistance to alopecia areata in C3H/HeJ mice is associated with increased expression of regulatory cytokines and a failure to recruit CD4+ and CD8+ cells. J Invest Dermatol. 2002 Dec;119(6):1426-33.

Freyschmidt-Paul P, McElwee KJ, Happle R, Kissling S, Wenzel E, Sundberg JP, Zoller M, Hoffmann R. Interleukin-10-deficient mice are less susceptible to the induction of alopecia areata. J Invest Dermatol. 2002 Oct;119(4):980-2. No abstract available.

Carroll JM, McElwee KJ, E King L, Byrne MC, Sundberg JP. Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol. 2002 Aug;119(2):392-402.

McElwee KJ, Hoffmann R. Alopecia areata - animal models. Clin Exp Dermatol. 2002 Jul;27(5):410-7.
20: Zoller M, McElwee KJ, Engel P, Hoffmann R. Transient CD44 variant isoform expression and reduction in CD4(+)/CD25(+) regulatory T cells in C3H/HeJ mice with alopecia areata. J Invest Dermatol. 2002 Jun;118(6):983-92.

McElwee KJ, Silva K, Beamer WG, King LE Jr, Sundberg JP. Melanocyte and gonad activity as potential severity modifying factors in C3H/HeJ mouse alopecia areata. Exp Dermatol. 2001 Dec;10(6):420-9.

Freyschmidt-Paul P, Ziegler A, McElwee KJ, Happle R, Kissling S, Sundberg JP, Hoffmann R. Treatment of alopecia areata in C3H/HeJ mice with the topical immunosuppressant FK506 (Tacrolimus). Eur J Dermatol. 2001 Sep-Oct;11(5):405-9.

Wiseman MC, Shapiro J, MacDonald N, Lui H. Predictive model for immunotherapy of alopecia areata with diphencyprone. Arch Dermatol 2001;137(8):1063-8.

Shapiro J, Lui H. Vaniqa--eflornithine 13.9% cream. Skin Therapy Lett 2001;6(7):1-3, 5.

Bissonnette R, Shapiro J, Zeng H, McLean DI, Lui H. Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata. Br J Dermatol 2000;143(5):1032-5.

Madani S, Trotter MJ, Shapiro J. Pseudopelade of Brocq in beard area. J Am Acad Dermatol 2000;42(5 Pt 2):895-6.

Hong C, McLean D, Shapiro J, Lui H. Using the Internet to Assess and Teach Medical Students in Dermatology. Arch Dermatol, September 2000.

McElwee K, Hoffmann R. Growth factors in early hair follicle morphogenesis. Eur J Dermatol. 2000 Jul-Aug;10(5):341-50.

Shapiro J, Sundberg JP, Bissonnette R, McElwee KJ, McLean DI, Carroll JM, Oliver RF, Tang L, Lui H. Alopecia areata-like hair loss in C3H/HeJ mice and DEBR rats can be reversed using topical diphencyprone. J Investig Dermatol Symp Proc. 1999 Dec;4(3):239.

McElwee KJ, Boggess D, Miller J, King LE Jr, Sundberg JP. Spontaneous alopecia areata-like hair loss in one congenic and seven inbred laboratory mouse strains. J Investig Dermatol Symp Proc. 1999 Dec;4(3):202-6.

McElwee KJ, Boggess D, King LE, Sundberg JP. Alopecia areata versus juvenile alopecia in C3H/HeJ mice: tools to dissect the role of inflammation in focal alopecia. Exp Dermatol. 1999 Aug;8(4):354-5.

Freyschmidt-Paul P, Sundberg JP, Happle R, McElwee KJ, Metz S, Boggess D, Hoffmann R. Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice. J Invest Dermatol. 1999 Jul;113(1):61-8.

McElwee KJ, Spiers EM, Oliver RF. Partial restoration of hair growth in the DEBR model for Alopecia areata after in vivo depletion of CD4+ T cells. Br J Dermatol. 1999 Mar;140(3):432-7.

Shapiro J, Sundberg JP, Bissonnette R, McElwee KJ, McLean DI, Carroll JM, et al. Alopecia areata-like hair loss in C3H/HeJ mice and DEBR rats can be reversed using topical diphencyprone. J Investig Dermatol Symp Proc 1999;4(3):239.